CYP2E1 and oxidative liver injury by alcohol
نویسندگان
چکیده
منابع مشابه
CYP2E1 is not involved in early alcohol-induced liver injury.
The continuous intragastric enteral feeding protocol in the rat was a major development in alcohol-induced liver injury (ALI) research. Much of what has been learned to date involves inhibitors or nutritional manipulations that may not be specific. Knockout technology avoids these potential problems. Therefore, we used long-term intragastric cannulation in mice to study early ALI. Reactive oxyg...
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There are three phases of alcoholic liver disease: fatty liver, which is usually reversible with abstinence; alcoholic hepatitis, or liver inflammation; and cirrhosis, or scarring of the liver. Patients frequently have more than one type of liver disease, such as coexisting fatty liver and alcoholic hepatitis or alcoholic hepatitis together with cirrhosis. Patients with both cirrhosis and alcoh...
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Alcohol consumption is customary in most cultures and alcohol abuse is common worldwide. For example, more than 50% of Americans consume alcohol, with an estimated 23.1% of Americans participating in heavy and/or binge drinking at least once a month. A safe and effective therapy for alcoholic liver disease (ALD) in humans is still elusive, despite significant advances in our understanding of ho...
متن کاملCYP2E1, oxidative stress and MAPK signaling pathways in alcohol-induced hepatotoxicity
In this review, we discuss studies on the role of CYP2E1 in alcohol-induced oxidative stress and how MAPK signaling cascades are involved in alcohol induced liver injury and fat accumulation. Many pathways have been suggested to play a role in how alcohol induces oxidative stress. Considerable attention has been given to alcohol elevated production of lipopolysaccharide (LPS) and TNFα and to al...
متن کاملConcerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver.
UNLABELLED Peroxiredoxins (Prxs) are peroxidases that catalyze the reduction of reactive oxygen species (ROS). The active site cysteine residue of members of the 2-Cys Prx subgroup (Prx I to IV) of Prxs is hyperoxidized to cysteine sulfinic acid (Cys-SO(2) ) during catalysis with concomitant loss of peroxidase activity. Reactivation of the hyperoxidized Prx is catalyzed by sulfiredoxin (Srx). E...
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ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2008
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2007.11.004